Endocrine Abstracts

Hypothesis: We hypothesised that damage to the hypothalamus by local tumour, surgical treatment, or irradiation might involve the suprachiasmatic nucleus and thereby melatonin secretion, leading to disturbed circadian function and clinical manifestations such as daytime sleepiness and fatigue in craniopharyngeoma patients.Objective: We aimed to assess the influence of craniopharyngiomas and their treatment on melatonin secretion, sleep pattern, sleep qua...

Introduction: Fractionated stereotactic radiotherapy (FSRT) is used in the treatment of surgically inaccessible meningiomas, primarily in the base of the skull. Development of hypopituitarism following FSRT is inexhaustively investigated. We aimed to elucidate the cause of hypopituitarism in patients treated with FSRT for benign meningiomas of the anterior skull base.Methods: All patients undergoing FSRT for benign meningioma of the skull base between Ju...

Introduction: Recently, it has been suggested that hypopituitarism developed after the brain injury has implications in the final recovery of the patients. We hypothesize that hypopituitarism developed in the course of traumatic brain injury (TBI) or non-TBI is related to worse functional outcome. The aim was to assess the association between hypopituitarism in the early recovery phase and long-term functional outcome.Materials and methods: We included 1...

Objective: To estimate the occurrence of hypopituitarism 12 months following traumatic brain injury (TBI), describe the time course, evaluate the predictive value of early hormonal changes and trauma related parameters, as well as out-come.Methods Forty-six patients with TBI (mild (GCS:13–15) n=22; moderate (GCS:9–13) n=9; severe (GCS<9) n=15) were included. Patients were tested early post-injury (baseline hormone level...

IntroductionPatients with pituitary adenomas undergoing transsphenoidal surgery require pre- and post-surgery examination of pituitary hormones. There is currently no consensus on how to evaluate the adrenal axis post-surgery. The aims of this study were to investigate factors that may predict postoperative adrenal insufficiency (AI) and to investigate the overall effect of transsphenoidal surgery on the pituitary function.Methods<...

Introduction: We questioned the justification of general recommendations for assessment of hypopituitarism in patients with traumatic brain injury (TBI), and aimed to describe the prevalence of hypopituitarism in a national TBI population of patients admitted to a Danish hospital in 2008, as compared to healthy controls.Patients and methods: We included 463 patients (18–65 years) hospitalized ≥24 h, with more than subtle TBI as indicated by lo...

Objective: Hypothalamic obesity results in severe weight-gain and increased risk of cardiovascular and metabolic mortality. We aimed to assess the safety and efficacy of Tesomet (tesofensine plus metoprolol), and ongoing requirements in pituitary hormone replacement adjustments in adults with acquired hypothalamic obesity, a rare disease with no approved therapyResearch design, patients and methodsTwenty-one adults with hypothalami...

Background and aim: The dual-release hydrocortisone Plenadren® has shown promising results of improved cardiovascular and metabolic profiles after treatment of adrenal insufficiency, possibly due to an improved circadian profile of cortisol, but results are ambiguous. Aim: To further investigate the potential effect of dual-release hydrocortisone on the metabolic profile as compared to conventional hydrocortisone in patients with secondary adrenal i...

Context: Assessment of disease control in acromegaly depends on GH and IGF-I, but discordant values frequently occur. Further, the role of OGTT-suppressed GH (GHnadir) in somatostatin analogue (SA) treated patients is debated.Objective: To evaluate the effect of targeting either IGF-I or GH during SA treatment.Design: A randomized, investigator-initiated, multicentre trial.Patients and methods: 84 ...

Background: Patients on long-term glucocorticoid treatment are at risk of adrenal insufficiency during glucocorticoid treatment. The side effect can occur during glucocorticoid treatment if there is a mismatch between glucocorticoid requirements and production/intake. High-dose glucocorticoid treatment is often sufficient to overcome most stressful situations. A low-dose of 5 mg prednisolone/day is however, equivalent to 20 mg hydrocortisone, a dose often used as basal glucoco...